Necrotic cell death: Harnessing the Dark side of the Force in mammary gland involution

Abstract

In response to major cellular insults, a massive increase in lysosomal membrane permeability (LMP) leads to necrosis. Data now reveal that this potent lysosomal-mediated necrotic cell-death machinery can also be harnessed for complex physiological processes, such as post-lactation mammary gland involution. © 2011 Macmillan Publishers Limited. All rights reserved.