Differentiating Delayed Esophageal Clearance From Reflux in Scleroderma

Abstract

Abnormal acid exposure to the esophagus and esophageal dysmotility leading to symptoms of refractory reflux and dysphagia are common findings amongst patients with advanced systemic scleroderma (SSc). Although treatments and diagnostic methods for esophageal disease in the setting of SSc are currently limited to those used for gastroesophageal reflux disease (GERD), certain advancements in diagnostic testing allow potential for improved detection of the exact etiology and clinical management. Through the lens of a case presentation, we found that while GERD is usually diagnosed with high acid exposure from decreased lower esophageal sphincter tone, the high esophageal acidity seen in scleroderma can be attributed to esophageal hypo-motility, leading to fermentation of food residue.