Association between treatment effects on disease progression end points and overall survival in clinical studies of patients with metastatic renal cell carcinoma

Abstract

Background: The relationship between progression-free survival and time to progression (PFS/TTP) and overall survival (OS) has been demonstrated in a variety of solid tumours but not in metastatic renal cell carcinoma (mRCC). Methods: A systematic literature search was conducted to identify controlled trials of cytokine or targeted therapies for mRCC reporting information on treatment effects on PFS/TTP and OS for one or more comparison. The associations between treatment effects on PFS/TTP and OS were analysed using linear regression. Results: Thirty-one studies representing 10 943 patients, 75 treatment groups, and 41 comparisons were identified. The correlation coefficient between the negative log of the hazard ratio (HR) for PFS/TTP (ln HRPFS/TTP) vs the negative log of the HR for OS (ln HROS) was 0.80 (P=0.0001). In linear regression, the coefficient on ln HR PFS/TTP vs ln HROS was 0.64 (95% confidence interval (CI): 0.47 0.81; R2 0.63), suggesting each 10% relative risk reduction (RRR) for PFS/TTP was associated with a 6% RRR for OS. A 1-month gain in medianPFS/TTP was associated with a 1.17-month gain in median OS (95% CI: 0.59,1.76; R2 0.28).Conclusion:In trials of treatments for mRCC, treatment effects on PFS/TTP are strongly associated with treatment effects on OS. © 2012 Cancer Research UK All rights reserved.