The rising prevalence of type 2 diabetes poses a serious threat to human health and the viability of many health care systems around the world. Although several prescription medications can play a vital role in controlling symptoms and preventing complications, non-adherence to these therapies is highly prevalent and has been linked to increases in morbidity, mortality, and health care costs. Although a vast array of significant adherence predictors has been identified, the ability to explain or predict non-adherence with known risk-factors remains poor. Further, the definitions, outcomes, and various measures used in the non-adherence literature can be misleading for the unfamiliar reviewer. In this narrative review, a practical overview of important considerations for interpreting adherence endpoints and measures is discussed. Also, an organizational framework is proposed to consider published adherence interventions. This framework may allow for a unique appreciation into areas of limited knowledge and thus highlights targets for future research. © 2013 Blackburn et al, publisher and licensee Dove Medical Press Ltd.
Blackburn, D. F., Swidrovich, J., & Lemstra, M. (2013, January). Non-adherence in type 2 diabetes: Practical considerations for interpreting the literature. Patient Preference and Adherence. https://doi.org/10.2147/PPA.S30613