Feeding Study with Bt Corn (MON810: Ajeeb YG) on Rats: Biochemical Analysis and Liver Histopathology

Abstract

Bt corn “MON810: Ajeeb YG” produces delta endotoxins in the whole plant due to the geneticmodification process. The chemical analysis of this variety showed significantdifferences from its conventional counterpart “Ajeeb”. Further, feeding studies on rats were designed to complete assessingthe safety of “MON810: Ajeeb YG”. Three groups of rats (6 males and 6 females’ rats/group) were fed on control diet, non-Bt corn and Bt corn for 1.5 months and 3 months.After 1.5 months, 3 males and 3 females from each groupwere sacrificed, and after another 1.5 months, 3 males and 3females from each group and their offspring were sacrificed. Histopathologicalexamination, blood haematology and serum biochemical analysis were determined.Results indicated significant differences among the tested parameters in thethree groups especially Bt group. Severe changes in the liver of Bt group after3 months were observed.