Effect of hepatitis C virus (HCV) genotype on HCV and HIV-1 disease

Abstract

The relationship between hepatitis C virus (HCV) genotype and HCV and human immunodeficiency virus (HIV) type 1 disease is not well defined. The present study analyzed data from a cohort of 207 HIV-1-infected and 126 HIV-1-uninfected children and adolescents with hemophilia who enrolled in the Hemophilia Growth and Development Study and were followed for 7 years. The mean HCV RNA level was higher in the participants in the HCV genotype 1 group than in the participants the HCV non-genotype 1 group, among both the HIV-1-infected (difference, +0.33 log10 copies/mL; P = .038) and HIV-1-uninfected (difference, +0.59 log10 copies/mL; P = .008) participants. Although HCV genotype was not associated with differences in HIV-1 RNA level, a significantly lower mean CD4+ T cell count (difference, -127 cells/μL; P = .026) and percentage of CD4+ T cells (difference, -4.3%; P = .027) were observed in the participants in the HCV genotype 1 group, compared with those in the participants in the HCV non-genotype 1 group. In addition, the participants in the HCV genotype 1 group were at increased risk for progression to AIDS-related mortality (hazard ratio, 2.44; P = .037). The present study suggests that HCV infection and genotype may influence the natural history of HCV and HIV-1 disease.