The effect of cholecalciferol on anxiety-related depression and hormonal state in women of reproductive age with premature ovarian failure

Abstract

The present study was aimed at estimating the effects of vitamin Dj (VDj, cholecalciferol) chronic treatment in various doses on the affective-related state and level of hormones in young women with premature ovarian failure. Vitamin Dj based commercial preparations Vigantol or Aquadetrim were administered during 6 months in 47 women aged 33-40 at daily doses of 20000 and 40000 lU together with standard menopausal hormone therapy (MHT) depending on the background anamnesis and accompanying gynecological diseases According to the clinical statements, we constantly monitored the emotional state and measured gonadal hormones and 25-OH-vd3 levels in the blood of patients tested. It was established that affective-related state symptoms in young women with premature ovarian failure treated with cholecalciferol at doses of 20000/40000 lU on the background of MHT therapy have been completely eliminated within 6 months of this treatment. Simultaneously with improvement of the psycho-emotional state of patients, the combined administration of cholecalciferol in various doses with MHT preparations also corrected the hormonal state (decreased FSH and LH levels with parallel increase of progesterone and estradiol concentrations) and increased vd3 levels in the blood serum more rapidly as compared to the young women with premature ovarian failiu-e given only MHT preparations. Thus, results of the present pilot clinical study suggest that combination of MHT with cholecalciferol at doses of20000/40000 lU (depending on individual 25-OH-vd3 levels) is very beneficial for pharmacological correction of affective-related disorders in young women with premature ovarian failure.