Abstract
Background: Circadian gene expression in mammals is driven by rhythmic CLOCK-BMAL1 activities. Results: Gm129 binds to the CLOCK-BMAL1 complex on DNA and represses its transcriptional activator activity to regulate the circadian gene expression phase. Conclusion: Gm129 is a novel circadian clock modulator. Significance: The discovery of Gm129 reveals a new regulatory component of circadian gene expression. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
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CITATION STYLE
Annayev, Y., Adar, S., Chiou, Y. Y., Lieb, J. D., Sancar, A., & Ye, R. (2014). Gene model 129 (Gm129) encodes a novel transcriptional repressor that modulates circadian gene expression. Journal of Biological Chemistry, 289(8), 5013–5024. https://doi.org/10.1074/jbc.M113.534651
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