Anxiety affects over 260 million people worldwide. Benzodiazepines are a class of agents used in combination with other therapies for the management of anxiety. Lorazepam is a commonly prescribed benzodiazepine metabolized by uridine 5'-diphosphate-glucuronosyltransferases. Herein, we discuss recent findings regarding the pharmacogenetics of uridine 5'-diphosphate-glucuronosyltransferase 2B15 (UGT2B15), lorazepam, and its role in the treatment of anxiety.
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CITATION STYLE
Ching, N. R., Alzghari, A. K., & Alzghari, S. K. (2018). The Relationship of UGT2B15 Pharmacogenetics and Lorazepam for Anxiety. Cureus. https://doi.org/10.7759/cureus.3133