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The Relationship of UGT2B15 Pharmacogenetics and Lorazepam for Anxiety

  • Ching N
  • Alzghari A
  • Alzghari S
Cureus (2018)
DOI: 10.7759/cureus.3133
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Abstract

Anxiety affects over 260 million people worldwide. Benzodiazepines are a class of agents used in combination with other therapies for the management of anxiety. Lorazepam is a commonly prescribed benzodiazepine metabolized by uridine 5'-diphosphate-glucuronosyltransferases. Herein, we discuss recent findings regarding the pharmacogenetics of uridine 5'-diphosphate-glucuronosyltransferase 2B15 (UGT2B15), lorazepam, and its role in the treatment of anxiety.

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Ching, N. R., Alzghari, A. K., & Alzghari, S. K. (2018). The Relationship of UGT2B15 Pharmacogenetics and Lorazepam for Anxiety. Cureus. https://doi.org/10.7759/cureus.3133

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