Comparison of hormonal levels between infertile PCOS and non-PCOS females

Abstract

Background: Polycystic ovary syndrome (PCOS) is a complex condition characterized by elevated androgen levels, menstrual irregularities cystic ovaries. Other clinical features include obesity, acne, amenorrhea, excessive hair growth, and infertility. PCOS has been linked to insulin resistance and obesity and many patients with PCOS have insulin resistance and hyper-insulinemia, which play a significant role in the pathogenesis of PCOS Method: This study was conducted during the period starting from November 2022 to May 2023. One hundred infertile female patients aged range 18–46 years. Women complaining from infertility included in this study were divided into 2 groups: Group I: PCOS group, including 42 females diagnosed with PCOS. Group II: Non-PCOS group, involving 58 females with either male factors or unexplained causes of infertility. Results: BMI was significantly higher among PCOS females (28.61 ± 1.06 vs.25.62 ± 1.65; p=0.046), there was significantly higher LH levels (6.12 ± 0.12 vs. 4.59 ± 0.31; p=004), LH/FSH ratio (1.20 ± 0.12 vs. 0.78 ± 0.05; p=0.001) and significantly lower FSH levels among PCOS patients (5.62 ± 0.62 vs. 6.67 ± 0.58; p=0.043). There were also no significant correlations among PCOS women between BMI with LH, FSH, LH/FSH ratio, E2, prolactin and testosterone hormones