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Failure of chlorpromazine to inhibit fluid accumulation caused by Escherichia coli heat-stable enterotoxin in suckling mice

Infection and Immunity (1981) 32(2) 480-483
DOI: 10.1128/iai.32.2.480-483.1981
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Abstract

We studied the effect of chlorpromazine on fluid accumulation caused by purified heat-stable enterotoxin (ST) from enterotoxigenic Escherichia coli in suckling mice. We found that chlorpromazine inactivated ST itself in vitro, but did not inhibit the activity of ST in the intestines.

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Takeda, T., Honda, T., Takeda, Y., & Miwatani, T. (1981). Failure of chlorpromazine to inhibit fluid accumulation caused by Escherichia coli heat-stable enterotoxin in suckling mice. Infection and Immunity, 32(2), 480–483. https://doi.org/10.1128/iai.32.2.480-483.1981

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