Human immunodeficiency virus and hepatitis C virus/hepatitis B virus co-infection in Southern Brazil: Clinical and epidemiological evaluation

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Abstract

Hepatitis B virus, hepatitis C virus and human immunodeficiency virus share a similar transmission pathway and are often diagnosed in the same patient. These patients tend to have a faster progression of hepatic fibrosis. This cross-sectional study describes the demographic features and clinical profile of human immunodeficiency virus/hepatitis co-infected patients in Paraná, Southern Brazil. A total of 93 human immunodeficiency virus-infected patients attending a tertiary care academic hospital in Southern Brazil were included. Clinical, demographic and epidemiological data were evaluated. Hepatitis B virus and/or hepatitis C virus positive serology was found in 6.6% of patients. The anti-hepatitis C virus serum test was positive in 85% (79/93) of patients, and the infection was confirmed in 72% of the cases. Eighteen patients (19%) were human immunodeficiency virus/hepatitis B virus positive (detectable HBsAg). Among co-infected patients, there was a high frequency of drug use, and investigations for the detection of co-infection were conducted late. A low number of patients were eligible for treatment and, although the response to antiretroviral therapy was good, there was a very poor response to hepatitis therapy. Our preliminary findings indicate the need for protocols aimed at systematic investigation of hepatitis B virus and hepatitis C virus in human immunodeficiency virus-infected patients, thus allowing for early detection and treatment of co-infected patients.

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Raboni, S. M., Tuon, F. F., Beloto, N. C. P., Demeneck, H., Oliveira, A., Largura, D., … Pedroso, M. L. (2014). Human immunodeficiency virus and hepatitis C virus/hepatitis B virus co-infection in Southern Brazil: Clinical and epidemiological evaluation. Brazilian Journal of Infectious Diseases, 18(6), 664–668. https://doi.org/10.1016/j.bjid.2014.05.011

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