Recent Advances in the Synthesis of Benzoheterocyclic Compounds Involving Isatins

Abstract

Isatin is a natural small molecule compound of the indole class. Due to its unique structure, low cost and easy availability, the use of isatin as a starting material to construct complex and diverse heterocyclic compounds has been a research hotspot in the field of organic synthesis. Since isatin possess rich reaction sites, it has a significant step advantage in converting it into similar heterocycles. In recent years, the great progress has been made in the construction of heterocyclic compounds based on domino reactions involving isatins. According to the different types of heterocycles, the research progress in the synthesis of benzoheterocyclic compounds by the domino reactions related to isatins is briefly discussed.