Application of embryonic stem cells in Parkinson's disease

Abstract

At present L-dopa as representative's dopamine substitution treatment primarily is mainly taken in clinic to treat Parkinson's disease, which has many drug side effect, and could not prevent the progress of patient's condition. The surgery therapy has the development in the recent years, but also has the flaws like patient's indication is limited; the long-term curative effect is not ideal. Thus, stem cells became the research focal point to cure Parkinson's disease and other nerve degenerative disease. Embryonic stem cells induced directional differentiation and formed nerve cells under the correlation factor function, through the mechanisms such as differentiating the dopaminergic neuron through the transplanted stem cells to exercise the function of normal cells, the function of protection and the nutrition of the dopaminergic neuron, promoting endogenous doparninergic nerve genesis and so on to cure nervous system degenerative disease like Parkinson's disease. But it still has certain side effects, and needs to undertake massive experimental studies and clinical trials. Embryonic stem cells provide a new technical platform for treating Parkinson's disease, which shows a promising prospect in treatment of the nervous system degenerative disease.