Parallel kinetic resolution of racemic amines using 3-n,n-diacylaminoquinazolin-4(3h)-ones

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Abstract

The two pseudoenantiotopic N-acyl groups of enantiopure 3-[N-(3-m-acetoxyphenylpropanoyl)-N-(3-phenylpropanoyl)amine]-2- isopropylquinazolin-4(3H)-one 7 each react with a different enantiomer of 2-methylpiperidine giving rise to efficient parallel kinetic resolution (ee > 95%).

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Al-Sehemi, A. G., Atkinson, R. S., & Meades, C. K. (2001). Parallel kinetic resolution of racemic amines using 3-n,n-diacylaminoquinazolin-4(3h)-ones. Chemical Communications, 24, 2684–2685. https://doi.org/10.1039/b109297a

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