Abstract
Disruptions of biometal-Aβ(1-40) interactions by an isoniazid-derived hydrazone, INHHQ, were demonstrated via in vitro NMR titrations. The compound has adequate theoretical BBB absorption properties, assessed by in silico studies. In vivo acute toxicity assays indicate that INHHQ is innocuous up to 300 mg kg-1, showing potential as an anti-Alzheimer's drug.
Cite
CITATION STYLE
Hauser-Davis, R. A., De Freitas, L. V., Cukierman, D. S., Cruz, W. S., Miotto, M. C., Landeira-Fernandez, J., … Rey, N. A. (2015). Disruption of zinc and copper interactions with Aβ(1-40) by a non-toxic, isoniazid-derived, hydrazone: A novel biometal homeostasis restoring agent in Alzheimer’s disease therapy? Metallomics, 7(5), 743–747. https://doi.org/10.1039/c5mt00003c
Register to see more suggestions
Mendeley helps you to discover research relevant for your work.
