Inhibition of tyrosine hydroxylase by aquayamycin

Abstract

Aquayamycin was found to be a strong inhibitor of tyrosine hydroxylase. It inhibits tyrosine hydroxylase by 50% at 3.7×10-7M. The inhibition is noncompetitive with tyrosine. The inhibition by 4×10-7 Maquayamycin increases when the concentration of 2-amino-4-hydroxy-6, 7-dimethyltetrahydropteridine is increased from 2×10-4M to 1×10-3M. The inhibition of tyrosine hydroxylase by aquayamycin is reversed by Fe++. © 1968, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.