Antimicrobial Peptide Cathelicidin and Vitamin D Receptor Gene Polymorphism in Oral Health

Abstract

Background: Anti-microbial peptides and vitamin D levels in saliva, GCF play an important role in oralhealth and its maintenance. The peptide levels are regulated by the Vitamin D cathecidilin pathway and theirassociation and influence on oral health is of outmost importance. The aim of the present review article is toestablish The aim is to establish a relationship and possibly the role of Cathelicidins and Vitamin D receptorgene polymorphism in relation to oral healthMethodology: The preferred reporting items for systematic review ad meta analysis (PRISMA) were usedfor reporting this systematic review. The study protocol has been approved by all co-authors .The study hasbeen registered at the National institute for health research (NHR) under the Prospero ID: CRD42020200946.Results: A total of 102 articles were retrieved through electronic database search .After evaluating the title,abstract and full text of these articles only 7 were selected for the present systematic review. However 3articles were excluded because they were classified as high risk of bias according to PRISMA guidelines.Out of 7 studies selected,4 were classified as low risk bias and 3 were classified as moderate riskbias.Conclusion: The current evidence suggests anti-microbial peptide LL-37 and vitamin D receptor genepolymorphism plays an important role in caries prevalence and periodontal healthHighlight: Understanding the role of antimicrobial peptides in saliva helps in enhancing focus on the effectof these components on oral health and its maintenance.