Critical Study of 5% Guanethidine in Ocular Manifestations of Graves's Disease

Abstract

Assessment was made of 5% local guanethidine in treating eye manifestations in euthyroid patients with either treated thyrotoxicosis or ophthalmic Graves's disease. In a double-blind crossover study guanethidine caused greater improvement in lid retraction than a control solution. A long-term study showed that this improvement was maintained. A much lower incidence of side-effects was noted with 5% guanethidine than with 10% solution. © 1969, British Medical Journal Publishing Group. All rights reserved.