Non-hydrolyzable RNA-peptide conjugates: A powerful advance in the synthesis of mimics for 3′-peptidyl tRNA termini

Abstract

Translation of specific small peptides on the ribosome can confer resistance to macrolide antibiotics. To reveal the molecular details of this and related phenomena, stable RNA-peptide conjugates that mimic peptidyl-tRNA would be desirable, especially for ribosome structural biology. A flexible solid-phase synthesis strategy now allows efficient access to these highly requested derivatives without restriction on the RNA and peptide sequences. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.