Predictive ability of serum osmolarity for contrast-induced nephropathy after elective percutaneous coronary intervention: Are we having a new target?

Abstract

Background: Contrast-induced nephropathy (CIN) remains a serious complication following percutaneous coronary intervention (PCI), often leading to poor outcomes. Although the overall incidence of CIN is low, the risk can be significantly higher in certain susceptible cohorts. Results: This prospective observational analytic study enrolled 174 consecutive eligible patients. The study selectively included diabetic patients with heart failure who are receiving regular diuretic therapy, being scheduled for elective coronary angiography (CAG) and/or PCI. CIN occurred in 24.7% of the study participants. CIN patients had significantly higher baseline osmolarity compared to those who did not develop CIN. After adjusting for other factors, pre-procedure osmolarity ≥ 302.3 mOsm/L, higher CHA2DS2VA score, and larger contrast volume proved to be independent predictors for CIN with an odds ratio and 95% confidence interval of 7.07 (2.47–20.26), 3.99 (2.02–7.9), and 1.01 (1.0–1.014), respectively. Conclusions: In patients at high risk for CIN, serum osmolarity can serve as a practical stratification tool for CIN risk before elective CAG or PCI. Future studies should evaluate whether targeting a specific pre-procedural osmolarity threshold can reduce the risk of post-PCI CIN.