Hormonal, Histological, and Sperm Parameters: A Comparative Study between Amitriptyline and Escitalopram in Male Mice

Abstract

This study was designed to compare between anti-depressants (amitriptyline and escitalopram) in terms of their impacts on sperm concentration, motility, and vitality, as well as their effect on the hormone level (FSH, LH, and testosterone). The histological sections of the testis and epididymis were stained by using the (PAS) method and the number of experimental 90 male mice was divided into three groups, of which one consisting of 30 male mice, the first group was administration orally normal saline, the second group was administration orally amitriptyline, and the third group was administration orally escitalopram at a dose (0.4 µl/day) twice a day, and continued to experience six weeks, and the results showed a decrease in the concentration and the sperm motility, and also an increase in the number of the dead sperm showed a decrease in hormone levels (FSH, LH, and testosterone) as well as the interaction of the basement membrane of testis and epididymis with PAS ranged from moderate to strong in both groups.