Determinantes fisiológicos do controle do peso e apetite

Abstract

Obesity is currently one of the main problems of public health, presenting multifactorial etiology. The main involved factors in the control of weight and appetite are neuronal, endocrine, adipocity and intestinal. Leptine and insuline are hormones produced proportionally to adipose mass and act stimulating the catabolism. In the central nervous system, insuline and leptine interact with hypothalamic receivers favoring the satiety. Individuals with obesity have high seric concentrations of these hormones and present resistance to their action. The intestinal peptides, associated with other signals, can stimulate (greline and orexine) or inhibit (CKK, leptine and oxymodulin) the food intake. All act in the hypothalamic centers, that are the major responsible for the nutrititional behavior.