The role of PAT in the development of telescoped continuous flow processes

Abstract

This review highlights the advantages of incorporating Process Analytical Technologies into continuous flow processes, especially in the context of telescoped multistep flow sequences. Use of FlowIR, in-line UV-vis, online HPLC, online MS and Flow NMR are discussed within this review, with multiple PAT techniques used in conjunction with one another in some instances. PAT is key in ensuring as much information as possible can be gathered during a chemical transformation, with real-time analysis allowing for rapid reaction optimization.