A simple and efficient procedure for synthesis of optically active 1, 3, 4-oxadiazole derivatives containing L-amino acid moieties

Abstract

Some new unsymmetrical and optically active 2, 5-disubstituted 1, 3, 4-oxadiazoles 5a-j were efficiently synthesized by cyclization reaction of diacylhydrazides 4a-j. The synthesis of the title compounds was achieved by the reaction of acyl hydrazides 3a-b and N-phetaloyl-L-amino acids 1a-e in the presence of the phosphoroxy chloride (POCl3) as an anhydrous reagent. © tübi̇tak.