Recurrences of anaphylaxis: Trends and risk factors

Abstract

Purpose of reviewRecurrences of anaphylaxis is a concern due to its unpredictability and long-term burden to patients and healthcare systems. This review examines recurrence rates, associated risk factors, and gaps in current knowledge to guide improved clinical management.Recent findingsFrom 1240 initial records, 11 studies fulfilled the inclusion criteria of our systematic review. Recurrences of anaphylaxis rates range from 2.6 to 17.6% of patients after a first episode of anaphylaxis, with a rising trend over time. Personal history of food allergy is the most consistent associated risk factor, followed by the presence of atopic comorbidities such as asthma and atopic dermatitis. Other potential factors include socioeconomic deprivation, and seasonal variations. There is lack of evidence on contributing factors to volve to more severe episodes and on how etiology may change between episodes.SummaryRecurrences of anaphylaxis is multifactorial, with personal history of food allergy and allergic comorbidities as primary risk factors. Inconsistencies across studies underscore the need for standardized research. Limited data on severity and etiology progression highlight areas for future investigation to improve long-term outcomes.