Modern analytical methods for consideration of natural biological activity

Abstract

Due to the structural diversity of natural compounds in plants kingdom and a wide range of beneficial properties for health, they are attractive to use for various applications. Natural bioactivity means pharmacological effects induced by compounds of interest, which can be a subject of change under different conditions and dependent on individual organism. Development of supercomputers, spectroscopy techniques, completion of human genome project led to development of computational techniques in drug design. Their application can significantly benefit drug discovery field by reducing experiments in vivo, thus preventing subjecting of ultimatively ineffective drug candidates to clinical trials and simultaneously making contribution to understanding initial disease complex mechanisms that can change, e.g. due to gene mutations. Therefore, bioactivity data for natural bioactive compounds as potential drug candidates needs to be constantly updated within sets of computerized collections. Current review focuses on modern computational techniques to study bioactivity of selected natural compounds.