The use of calcium carbide in the synthesis of 1-monosubstituted aryl 1,2,3-triazole via click chemistry

Abstract

The synthesis of 1-monosubstituted aryl 1,2,3-triazoles was achieved using calcium, carbide as a source of acetylene. The copper-catalyzed 1,3-dipolar cycloaddition reactions were carried out without nitrogen protection and in a MeCN - H2O mixture. The yields ranged from moderate to excellent. The reaction conditions were found to be successful for aryl azide reactants, including analogues with various functionalities.