Versatile mechanisms of 2-substituted benzimidazoles in targeted cancer therapy

Abstract

The aim of this review is to provide an overview on diverse anticancer activities of 2-substituted benzimidazole derivatives. This review provides a correlation between the various mechanisms of action of benzimidazoles as anticancer and the substitution pattern around the nucleus. The linker group and substitution at N-1, C-2, C-5, and C-6 positions have been found to be the most contributory factors for anticancer activity. This will help in the further design to afford more selective, potent, and multi-target anticancer of 2-substituted benzimidazole-based compounds.