Occurrence of gastric ulcers in gnotobiotic piglets colonized by Helicobacter pylori

Abstract

Archival gastric tissues from 10 of 39 gnotobiotic piglets colonized with Helicobacter pylori 26695 contained stromal leukocytic inflammation along with ulcers and erosions. In contrast, gastric tissues from 54 archival control piglets were devoid of both inflammation and ulcers. These data confirm the hypothesis that H. pylori infection alone is ulcerogenic.