Nanaomycins, New Antibiotics Produced by a Strain of Streptomyces. I. Taxonomy, Isolation, Characterization and Biological Properties

Abstract

Nanaomycins are new antibiotics produced by the strain OS-3966 which was designated Streptomyces rosa var. notoensis. Nanaomycins A and B were isolated from the culture filtrate by extraction with organic solvent and silica gel chromatography. The physical and chemical properties suggest that nanaomycins A and B are quinone-related compounds having the molecular formulae, C16H14O6 and C16H16O7, respectively. Nanaomycins A and B inhibit mainly mycoplasmas, fungi and Gram-positive bacteria. The acute toxicities (LD50. ip) of nanaomycins A and B in mice are 28.2 and 169 mg/kg, respectively. © 1975, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.