Metformin and sex: Why suppression of aging may be harmful to young male mice

Abstract

Intriguingly, in this issue of Aging, Anisimov et al. reported that lifelong treatment with metformin (an antidiabetic drug with potentially anti-aging effects) was beneficial for female mice but shortened lifespan in males. Here I discuss why suppression of aging may be unfavorable in young males. © Blagosklonny et al.