Novel Polymeric in Situ Gel Forming System for Ophthalmic Drug Delivery

Abstract

In the present update controlled and sustained drug delivery has become the standard in modern Pharmaceutical design and an intensive research have been undertaken in achieving much better drug product effectiveness, reliability and safety. This interest has been sparked by the advantages shown by in situ forming polymeric delivery systems such as ease of administration and reduced frequency of administration, improved patient compliance and comfort because of sustained and prolonged action in comparison to conventional drug delivery systems. The formation of gels depends on factors like temperature modulation, pH change, presence of ions and ultra violet irradiation, from which the drug gets released in a sustained and controlled manner. Various biodegradable polymers that are used for the formulation of in situ gels include chitosan, pluronics, xyloglucans, hydroxy propyl methyl cellulose, carbopol, gelrite, gellan gum, hyaluronic acid and alginates. Mainly in situ gels are administered by oral, ocular, rectal, vaginal, injectable and intraperitoneal routes. From a manufacturing point of view, the production of such systems is less complex and thus lowers the investment and manufacturing cost. The present study focused on the polymers used in the preparation of in situ gelling system for the ophthalmic drug delivery.