Ebola virus and its immunopathogenesis - A review

Abstract

Ebola virus, a highly pathogenic DNA virus, is associated with severe systemic complications in both man and animals. Ebola virus is transmitted through direct and indirect contact. The first Ebola virus outbreak was due to the zoonotic transmission followed by human to human. These viruses encompass serious pathophysiological events like systemic viral replication, immune suppression, abnormal inflammatory responses, major fluid and electrolyte losses and high mortality. Diagnosis and laboratory tests, typically real time reverse transcription PCR is used to detect viral genome. The 2013-2016 outbreak was classified by WHO as a public health emergency of international concern, which drew attention to the challenges of diseases caused by infection with Ebola virus and societal preparation to handle future epidemics. This review throws insight on the immune-pathogenesis of ebola viruses from the articles retrieved from various search engines like Pubmed and Google scholar.