High symmetry chiral auxiliaries containing heteroatoms

Abstract

Based on 1,1 '-binaphthalene-2,2'-diol 1, that is considered the prototype of the class of "man-made" chiral auxiliaries possessing C2 symmetry, a variety of other chiral molecules containing the binaphthyl or biphenyl skeleton has been developed. Among them, 1,1-binaphthalene-2,2'-dithiol 2 is the one that has experienced the largest assortment of applications.