Contractions to 5‐hydroxytryptamine in human coronary artery and human saphenous vein.

Abstract

Isometric contractions were obtained to 5‐hydroxytryptamine receptor agonists in human saphenous vein and human coronary artery. Based on the interaction with the 5‐HT2 receptor antagonist ketanserin, both 5‐ HT1 and 5‐HT2 receptors are involved in contractions of human saphenous vein, but the predominant subtype involved in contractions of human coronary artery is the 5‐HT1 receptor. 1990 The British Pharmacological Society