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Genome-Wide Scan for a Healthy Aging Phenotype Provides Support for a Locus Near D4S1564 Promoting Healthy Aging

Journals of Gerontology - Series A Biological Sciences and Medical Sciences (2004) 59(3) 227-232
DOI: 10.1093/gerona/59.3.b227
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Abstract

Living to a late age without suffering any major health problems is a genetically influenced trait. To identify the genes contributing to this important phenotype, a 10 cM genome screen was performed in 95 pairs of male fraternal twins concordant for healthy aging. Individuals meeting these criteria were defined as those attaining the age of 70 free of cardiovascular disease (coronary surgery, diabetes, heart attack, and stroke) and prostate cancer. Six chromosomal regions were identified with logarithm of odds (LOD) scores greater than 1.2 (p

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Reed, T., Dick, D. M., Uniacke, S. K., Foroud, T., & Nichols, W. C. (2004). Genome-Wide Scan for a Healthy Aging Phenotype Provides Support for a Locus Near D4S1564 Promoting Healthy Aging. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 59(3), 227–232. https://doi.org/10.1093/gerona/59.3.b227

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