CAMP-response element-binding protein (CREB) and NF-κB transcription factors are activated during prolonged hypoxia and cooperatively regulate the induction of matrix metalloproteinase MMP1

Abstract

Background: Changes in gene expression mediate adaption to hypoxia. Results: MMP1 was induced during prolonged hypoxia, and this induction was blocked after depletion of CREB and/or NF-κB. Conclusion: CREB and NF-κB mediate the up-regulation of MMP1 during prolonged hypoxia. Significance: CREB-and NF-κB-mediated gene transcription may play a major role in the cellular response to prolonged hypoxia. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.