Comparison the effects of ketamine alone and ketamine-diazepam combination in dogs of local breed in Mekelle, Ethiopia

Abstract

An experimental study was conducted to evaluate the effects of ketamine alone and with diazepam combination on anesthetic parameters; on physiological and hematological parameters so as to choose a suitable general anesthetic combination for use in surgical procedures in local breed of dogs in Mekelle, Ethiopia. The experimental study was carried out on ten local breed of dogs and were randomly divided in to two groups with five dogs in each group. Data was collected for analyzing physiological effects of anesthetic combinations; anesthetic effects and hematological effects using physical recording and laboratory analysis. The results of this study showed duration of general anesthesia was (44.8 ± 1.92min) and animal recovered (55.6 ± 3.85min) in diazepam –ketamine combination whereas duration of general anesthesia was (30 ± 1.05min) in ketamine alone. The result also showed that the physiological and hematological parameters remained significantly unchanged during the anesthesia in both groups. Therefore, relation duration of action, diazepam and ketamine combination was a suitable choice for undertaking of surgical operations in dogs of local breed for longer duration of action i.e, (44.8 ± 1.92min). Further studies on several other anesthetic combinations i.e. (acepromazine + xylazine + ketamine and acepromazine + diazepam + ketamine) on local breed of dogs and several other anesthetic combinations may be conducted.