Versatile microwave-assisted and lanthanum chloride catalysed synthesis of polysubstituted imidazoles using urea/thiourea as benign source of ammonia

Abstract

Lanthanum chloride was found to be an effective catalyst for the facile and one-pot synthesis of polysubstituted imidazoles under solvent free condition in excellent yields. This method elucidates urea/thiourea, as an environmentally benign source of ammonia for the synthesis of polysubstituted imidazoles. The work-up procedure is very simple and the products don't require further purification. © 2012 Hindawi Publishing Corporation.