The Strategies of Natural Polysaccharide in Wound Healing

Abstract

Severe or chronic wounds related to diseases or serious incidents have received big attention from not only a scientific standpoint but also a business perspective. Therefore, an effective treatment to abridge the long-term hospitalization of severe wound becomes indispensable. Glycosaminoglycan (GAG), one of the extracellular matrix molecules produced by fibroblasts, participates in cell-cell and cell-matrix interactions, in cell proliferation and migration, and in cytokine and growth factor signaling associated with all phases of wound recovery. Natural polysaccharide, for example, calcium alginate, which consists of mainly differing ratios of d-mannuronic and l-guluronic acid and rich of calcium ions, has been demonstrated to functionalize the glycosaminoglycan activity during wound healing. Once the trigger of the underlying wound healing mechanisms was understood, it should be possible to find ways to enhance and resolve the wound healing process in the patient with conditions and may lead to the potential for treatment alternatives in the future clinical field.