Problem-solving Test: The mechanism of action of a human papilloma virus oncoprotein

Abstract

Terms to be familiar with before you start to solve the test: human papilloma virus; cervical cancer; oncoproteins; malignant transformation; retinoblastoma protein; cell cycle; quiescent and cycling cells; cyclin/cyclin-dependent kinase (Cdk) complexes; E2F; S-phase genes; enhancer element; proto-oncogenes; tumor suppressor genes; radioactive labeling; immunoprecipitation; SDS-polyacrylamide gel electrophoresis; autoradiography; protein phosphorylation and dephosphorylation; gene induction; agarose beads; centrifugation; Western blot analysis; phases of cell cycle; generation time. © 2009 by The International Union of Biochemistry and Molecular Biology.