Chédiak and higashi's disease probable identity of “a new leucocytal anomaly (chédiak)” and “congenital gigantism of peroxidase granules (higashi)”

Abstract

Higashi published “Congenital Gigantism of Peroxidase Granules” in Sept. 1953, in which I was very much interested, because I had not seen any case of such an abnormity during my own 30 years' experience with the peroxidase reaction. Then I happened to read an article published in 1952 by Chédiak: Nouvelle anomalie leucocytaire de caractère constitutionnel et familial. On perusal, I came to consider both diseases as two different manifestations of one and the same clinical entity, though there was no description of peroxidase or oxidase raaction in Chédiak's paper. So I desire to suggest for this new clinical entity the name: Chédiak and Higashi's Disease or Chédiak-Higashi's Leuco-anomaly. © 1955, Tohoku University Medical Press. All rights reserved.