In vitro activities of pexiganan and 10 comparator antimicrobials against 502 anaerobic isolates recovered from skin and skin structure infections

Abstract

Pexiganan, a cationic peptide, exhibited a broad range of anti-anaerobic antimicrobial activity. The MIC90s of studied isolates were as follows: Bacteroides fragilis, 16 g/ml; other B. fragilis group spp., 4 g/ml; Prevotella and Fusobacterium spp., 32 g/ml; Porphyromonas spp., 64 g/ml; Propionibacterium acnes, 4 g/ml; Eggerthella lenta and Peptostreptococcus anaerobius, 32 g/ml; other Gram-positive rods and cocci, 4 g/ml; Clostridium perfringens, 128 g/ml; and other clostridia, 256 g/ml. Pexiganan cream shows potential as adjunctive therapy for skin and skin structure infections (SSSIs) involving anaerobes.