Myocardial infarction in the conscious dog: Three-dimensional mapping of infarct, collateral flow and region at risk

Abstract

Myocardial infracts were examined in dogs to determine the spatial distribution of infarction in the region at risk and the relation between infarction and collateral blood flow. Permanent occlusion of the left circumflex (LC) coronary artery at a constant site was made in 27 conscious dogs that were sacrificed 2 days later. The anatomic region at risk was defined by postmortem coronary arteriography as the volume of the occluded LC coronary bed. The masses of the left ventricle (LV), infract (I) and risk region (R) were calculated from planimetered areas of weighed 'bread-loaf' sections of LV. Infract size was directly related to the mass of the risk region (I = 0.53 R - 9.87; r = 0.97; p<0.001). There was no infraction when R was less than about 20 g or 20% of the LV. The infracts were mainly subendocardial and tapered from base to apex of the LV; 34% of the risk region became infarcted at the base compared with 22% at the apex. In all dogs, a significant rim of noninfarcted myocardium was identified at lateral aspects of the risk region, even at the endocardial surface. Using 9-μ radioactive microspheres, initial postocclusion flow at the margin of the infract, but weel within the risk region, was higher than at the center, and outer flows were higher than inner flows. Postocclusion flow was even higher in the noninfarcted rim within the risk region, but was still significantly less than flow to normal, nonriks areas. Collateral flows throughout the risk region increased during the first hour after conclusion, and were even higher at 2 days. Epicardially and laterally within the anatomic risk region there is a substantial amount of tissue that does not infarct despite initially reduced blood flow.