CLL microenvironment: Macro important

Abstract

In this issue of Blood, Herishanu and colleagues demonstrate that the lymph node is a key site in pathogenesis of chronic lymphocytic leukemia (CLL), where increased signaling through the B-cell receptor (BCR) contributes to proliferation and tumor progression.1 These results have key implications in future laboratory models of CLL, and emphasize the importance of the BCR pathway as a therapeutic target for this disease.