Novel pyrazole substituted oxazole derivatives: Design, insilico studies, synthesis & biological activities

Abstract

A potent antibacterial drug was developed by synthesizing a set of new pyrazoles substituted oxazole derivatives using multi-step synthesis. FT-IR,1H-NMR, Mass spectroscopy, and bases of microanalyses are employed to confirm the structure of compounds. Molinspiration online tool was used to predict the molecular properties and molecular docking was used to predict the antitubercular potency of the target compounds. 10-Fold serial dilution method, agar streak dilution test, and DPPH radical scavenging methods are utilized to evaluate antitubercular, antibacterial, and radical scavenging properties of test compounds and reference drugs, respectively. Varying degree of antitubercular, antibacterial, and radical scavenging activities (mild to good) was displayed by synthesized oxazole compounds. In general, unsubstituted oxazole derivatives exhibited superior antibacterial potency than substituted analogs. In addition, meta-substituted analogs displayed higher activity than the corresponding para-substituted analogs. Among fifteen tested target compounds, the potent compound of this series was found to be 4-(4-(5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)benzylidene)-2-methyloxazol-5(4H)-one (PBO8). Hence, this analog may be used as a lead molecule to find potent & safer antibacterial agents.