In vivo optical imaging of amyloid aggregates in brain: Design of fluorescent markers

Abstract

(Figure Presented) Routine diagnostics and studies of Alzheimer's disease might benefit form the noninvasive optical imaging of amyloid-β plaques in the brain. A rational design strategy for in vivo amyloid-imaging agents that enter the brain and selectively stain amyloid plaques is presented (see picture), and properties of a promising lead biomarker candidate are reported. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.