The crosstalk between lncRNA and microRNA in cancer metastasis: Orchestrating the epithelial-mesenchymal plasticity

Abstract

Noncoding RNAs (ncRNAs) have been demonstrated to closely associate with gene regulation and encompass the well-known microRNAs (miRNAs), as well as the most recently acknowledged long noncoding RNAs (lncRNAs). Current evidence indicates that lncRNAs can interact with miRNAs and these interactions play crucial roles in cancer metastasis, through regulating critical events especially the epithelialmesenchymal transition (EMT). This review summarizes the types of lncRNAmiRNA crosstalk identified to-date and discusses their influence on the epithelialmesenchymal plasticity and clinical metastatic implication.