The Nuclear Compartmentation of Glutathione: Effect on Cell Cycle Progression

Abstract

The oxidizing environment, shared by all aerobic organisms and crucial for their survival, poses a continuous threat to cellular structures all the living beings are made of. Structural proteins and lipids, and cellular membranes they compose, nucleic acids and enzymes that govern vital cellular processes are all susceptible to oxidative damage. Dealing with this inevitable and constant danger is one of the greatest challenges the living being with aerobic metabolism has to meet.